Search results for "corneal wound healing"

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Effects Of COOH-terminal tripeptide alpha-MSH (11-13) on corneal epithelial wound healing:role of nitric oxide

2006

It is known that alpha-melanocyte stimulating hormone (alpha-MSH) may exert anti-inflammatory effects and facilitate reparative processes in different tissues. The effective message sequence of alpha-MSH resides in the COOH-terminal tripeptide alpha-MSH(11-13). This study was undertaken to investigate the effects of topical administration of the COOH-terminal tripeptide sequence of alpha-MSH (alpha-MSH(11-13), KPV) on corneal epithelial wound healing in rabbits and the possible role of nitric oxide (NO) in these effects. The whole corneal epithelium was denuded in both eyes by mechanical abrasion. The area of the corneal epithelial defect was stained with fluorescein, photographed, and then…

MaleNitroprussideMelanocyte-Stimulating Hormonemedicine.medical_treatmentCorneal abrasionRabbitPharmacologyKPVNitric OxideNitric oxideCellular and Molecular Neurosciencechemistry.chemical_compoundPeptide Fragmentα-MSHmedicineAnimalsEnzyme InhibitorNitric Oxide DonorsMelanocyte-Stimulating HormonesFluoresceinEnzyme InhibitorsSalineCells CulturedCorneal epitheliumCell ProliferationEpithelial CellWound HealingbiologyDose-Response Relationship DrugAnimalcorneal wound healingEpithelium CornealEpithelial CellsNitric Oxide Donormedicine.diseaseSensory SystemsPeptide FragmentsNitric oxide synthaseOphthalmologymedicine.anatomical_structureNG-Nitroarginine Methyl EsterchemistryBiochemistrybiology.proteinSodium nitroprussideRabbitsWound healingmedicine.drug

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